FlyBase Allele Report: Dmel\sav[UAS.WT]

General Information

Symbol

Dmel\sav^UAS.WT

Species

D. melanogaster

Name

FlyBase ID

FBal0327414

Feature type

allele

Associated gene

Dmel\sav

Associated Insertion(s)

Carried in Construct

P{UAS-sav.WT}

Also Known As

UAS-sav

Key Links

Transgenic product class

wild_type

(Wehr et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Wehr et al., 2013)

Mutagen

in vitro construct

(Wehr et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-sav.WT}

Cytology

Description

UAS regulates expression of wild type sav.

(Wehr et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

sav

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^en.PU

(Yeom et al., 2020)

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Yeom et al., 2020)

abnormal size | adult stage, with Scer\GAL4^rn.PU

(Aerne et al., 2015)

decreased occurrence of cell division | larval stage, with Scer\GAL4^en.PU

(Yeom et al., 2020)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Yeom et al., 2020)

wing, with Scer\GAL4^en.PU

(Yeom et al., 2020)

wing, with Scer\GAL4^rn.PU

(Aerne et al., 2015)

wing disc posterior compartment, with Scer\GAL4^en.PU

(Yeom et al., 2020)

Detailed Description

Statement

Reference

Expressing sav^UAS.WT under the control of Scer\GAL4^en.PU results in a small but significant decrease in wing size.

(Yeom et al., 2020)

The expression of sav^Scer\UAS.WT under the control of Scer\GAL4^rn.PU leads to a significant decrease in wing area, as compared to controls.

(Aerne et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^en.PU, sav^UAS.WT has abnormal size | adult stage phenotype, suppressible by AsnRS^UAS.cYa, Scer\GAL4^en.PU

(Yeom et al., 2020)

Scer\GAL4^en.PU, sav^UAS.WT has decreased occurrence of cell division | larval stage phenotype, suppressible by AsnRS^UAS.cYa, Scer\GAL4^en.PU

(Yeom et al., 2020)

Scer\GAL4^ey.PH, sav^UAS.WT has abnormal size | adult stage phenotype, suppressible by AsnRS^UAS.cYa, Scer\GAL4^ey.PH

(Yeom et al., 2020)

Scer\GAL4^rn.PU, sav^UAS.WT has abnormal size | adult stage phenotype, suppressible | partially by Herc4^UAS.cAa, Scer\GAL4^rn.PU

(Aerne et al., 2015)

NOT suppressed by

Statement

Reference

Scer\GAL4^rn.PU, sav^UAS.WT has abnormal size | adult stage phenotype, non-suppressible by Herc4^C-A.UAS, Scer\GAL4^rn.PU

(Aerne et al., 2015)

Scer\GAL4^rn.PU, sav^UAS.WT has abnormal size | adult stage phenotype, non-suppressible by Herc4^C6.3/Herc4^C6.3

(Aerne et al., 2015)

Suppressor of

Statement

Reference

sav^UAS.WT, Scer\GAL4^en.PU is a suppressor of abnormal size | adult stage phenotype of AsnRS^UAS.cYa, Scer\GAL4^en.PU

(Yeom et al., 2020)

sav^UAS.WT, Scer\GAL4^en.PU is a suppressor of increased occurrence of cell division | larval stage phenotype of AsnRS^UAS.cYa, Scer\GAL4^en.PU

(Yeom et al., 2020)

sav^UAS.WT, Scer\GAL4^ey.PH is a suppressor of abnormal size | adult stage phenotype of AsnRS^UAS.cYa, Scer\GAL4^ey.PH

(Yeom et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^en.PU, sav^UAS.WT has wing disc posterior compartment phenotype, suppressible by AsnRS^UAS.cYa, Scer\GAL4^en.PU

(Yeom et al., 2020)

Scer\GAL4^ey.PH, sav^UAS.WT has eye phenotype, suppressible by AsnRS^UAS.cYa, Scer\GAL4^ey.PH

(Yeom et al., 2020)

Scer\GAL4^en.PU, sav^UAS.WT has wing phenotype, suppressible by AsnRS^UAS.cYa, Scer\GAL4^en.PU

(Yeom et al., 2020)

Scer\GAL4^rn.PU, sav^UAS.WT has wing | adult stage phenotype, suppressible | partially by Herc4^UAS.cAa, Scer\GAL4^rn.PU

(Aerne et al., 2015)

NOT suppressed by

Statement

Reference

Scer\GAL4^rn.PU, sav^UAS.WT has wing | adult stage phenotype, non-suppressible by Herc4^C-A.UAS, Scer\GAL4^rn.PU

(Aerne et al., 2015)

Scer\GAL4^rn.PU, sav^UAS.WT has wing | adult stage phenotype, non-suppressible by Herc4^C6.3/Herc4^C6.3

(Aerne et al., 2015)

Suppressor of

Statement

Reference

sav^UAS.WT, Scer\GAL4^en.PU is a suppressor of wing phenotype of AsnRS^UAS.cYa, Scer\GAL4^en.PU

(Yeom et al., 2020)

sav^UAS.WT, Scer\GAL4^en.PU is a suppressor of wing disc posterior compartment phenotype of AsnRS^UAS.cYa, Scer\GAL4^en.PU

(Yeom et al., 2020)

sav^UAS.WT, Scer\GAL4^ey.PH is a suppressor of eye phenotype of AsnRS^UAS.cYa, Scer\GAL4^ey.PH

(Yeom et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

The decreased wing area resulting from the expression of sav^Scer\UAS.WT under the control of Scer\GAL4^rn.PU is partially suppressed by the co-expression of Herc4^Scer\UAS.cAa or by Herc4^C6.3 homozygosity, but not by the co-expression of Herc4^C-A.Scer\UAS.

(Aerne et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sav^Scer\UAS.WT

sav^UAS.WT

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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