FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gcmR59L.UAS.Tag:FLAG
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General Information
Symbol
Dmel\gcmR59L.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0327472
Feature type
allele
Associated gene
Dmel\gcm
Associated Insertion(s)
Carried in Construct
P{UAS-gcm.R59L.FLAG}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Xi et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Xi et al., 2017)
Mutagen
in vitro construct
(Xi et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-gcm.R59L.FLAG}
Cytology
Description

UAS regulatory sequences drive expression of gcm with an N-terminal mutation (R59L), tagged with 3xTag:FLAG.

(Xi et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
gcm
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:9,581,417..9,581,417 [-]
Nucleotide change:

G9581417T

Amino acid change:

R59L | gcm-PA; R59L | gcm-PB

Reported amino acid change:

R59L

Comment:

Analogous R47L mutation in human GCM2 implicated in hypoparathyroidism, familial isolated; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Xi et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  hypoparathyroidism
      CEA
      (Xi et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Xi et al., 2017)
      GCM2:p.Arg47Leu
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: GCM2_6091
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of one or two copies of gcmR59L.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4sca.PU in embryos leads to a significant increase in glial cell population, as compared to controls.

      Expression of gcmR59L.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4hs.PU (induced during embryogenesis by heat shock at 6 hours AEL) leads to an increase in glial cells at both 11-12 hrs and 15-16 hrs AEL.

      (Xi et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      gcmR59L.Scer\UAS.T:Zzzz\FLAG
      gcmR59L.UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)