FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mh6
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General Information
Symbol
Dmel\mh6
Species
D. melanogaster
Name
FlyBase ID
FBal0327558
Feature type
allele
Associated gene
Dmel\mh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Tang et al., 2017)
Mutagen
Delta2-3 transposase
(Tang et al., 2017)
Progenitor genotype
P{SUPor-P}mhKG05829
(Tang et al., 2017)
Cytology
Description

Imprecise excision allele generated by mobilizing P{SUPor-P}mhKG05829, resulting in a deletion within mh ( X:15 ,474,352..15,474,733, release 6); this deletion includes the HEXXH active site.

(Tang et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:15,474,352..15,474,733 [-]
Comment:

382 bp deletion resulting from the imprecise excision of P{SUPor-P}mhKG05829. The deletion was reported to map to X:15 ,474,352..15,474,733 in R5 coordinates but they are actually R6 coordinates.

(Tang et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos from mh6 homozygous females lose their paternal chromosomes during and after the first zygotic mitosis, during the subsequent haploid mitoses the embryos show various degrees of aneuploidy, condensation and segregation defects.

      mh6 heterozygous or homozygous single mutant females produce comparable number of eggs relative to wild-type flies and the size of their ovaries appears normal.

      (Tang et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Top235-5/Top217-3, mh6/mh[+] has ovary phenotype

      (Tang et al., 2017)

      Top235-5/Top217-3, mh6 has ovary phenotype

      (Tang et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mh6/+;Top217-3/Top235-5 mutant females show much reduced fecundity (as compared to wild-type or mh6/+ female flies), mh6/mh6;Top217-3/Top235-5 double mutant flies are even less fecund and stop laying eggs completely by day 20 post-eclosion. Both the mh6/+;Top217-3/Top235-5 and the mh6/mh6;Top217-3/Top235-5 mutant females have ovaries of drastically reduced size, more so in the line homozygous for mh6.

      (Tang et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      mh1

      (Tang et al., 2017)
      Rescued by

      mh6/mh1 is rescued by mh+t5.8

      (Tang et al., 2017)

      mh6/mh1 is rescued by mhEGFP

      (Tang et al., 2017)

      mh6 is rescued by mh+t5.8

      (Tang et al., 2017)

      mh6 is rescued by mhEGFP

      (Tang et al., 2017)

      mh6/mh9 is rescued by mh+t5.8

      (Tang et al., 2017)

      mh6/mh9 is rescued by mhEGFP

      (Tang et al., 2017)

      mh6/mh31 is rescued by mh+t5.8

      (Tang et al., 2017)

      mh6/mh31 is rescued by mhEGFP

      (Tang et al., 2017)

      mh6/mh18 is rescued by mh+t5.8

      (Tang et al., 2017)

      mh6/mh18 is rescued by mhEGFP

      (Tang et al., 2017)
      Comments

      The maternal-effect lethality of progeny of mh6 homozygotes as well as all trans-heterozygous combinations of mh1, mh9, mh31, mh18, mh6 and Df(1)shtdEPDelta can be rescued by combination with either mh+t5.8 or mhEGFP.

      (Tang et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mh6
      (Castillo et al., 2022, Tang et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)