FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mip120LL07629
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General Information
Symbol
Dmel\mip120LL07629
Species
D. melanogaster
Name
FlyBase ID
FBal0336651
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
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Allele class
Mutagen
    Nature of the Allele
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    Mutagen
    Progenitor genotype
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    Cytology
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    Allele components
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    Mutations Mapped to the Genome
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    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
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    Marker for
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    Human Disease Associations
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    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
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    mip120LL07629/Df(2R)BSC274 mutant females have much smaller ovaries and the terminal egg chamber development show a consistent arrest, apparently between stages 7 and 8, in all ovarioles. The most mature egg chambers in each mutant ovariole are ovoid and contain a uniform layer of cuboidal follicle cells surrounding 15 nurse cells and a posterior oocyte, the ploidy of these nurse cells is estimated at 256C based on their nuclear diameter; apparently normal ring canals connect the nurse cells and the oocyte. The oocyte has a distinct germinal vesicle containing a small karyosome with decondensed DNA but lacks yolk.

    In egg chambers containing mip120LL07629 mutant germline clones surrounded by mip120LL07629/+ follicle cells the mutant nurse cells show nuclear defects (persistent undispersed and condensed chromosomes), whereas in egg chambers containing mip120LL07629 somatic clones with mutant follicle cells enveloping mip120LL07629/+ germline cells the nurse cells display normal nuclear morphology with chromosome disassembly and dispersion.

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    Mutant
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    Stocks (1)
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    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    mip120LL07629
    Name Synonyms
    Secondary FlyBase IDs
      References (1)