FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cirl3xCD4
Open Close
General Information
Symbol
Dmel\Cirl3xCD4
Species
D. melanogaster
Name
FlyBase ID
FBal0336674
Feature type
allele
Associated gene
Dmel\Cirl
Associated Insertion(s)
TI{TI}Cirl3xCD4
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Scholz et al., 2017)
Progenitor genotype
CirlKO.attP.w-
(Scholz et al., 2017)
Associated Insertion(s)
TI{TI}Cirl3xCD4
Cytology
Description

Insertion of a genomic Cirl fragment at the attP site in CirlKO.attP.w-; the fragment contains a triple CD4 immunoglobulin repeat spacer cassette (marked with poly-Tag:V5 tags) that results in elongation (approximately 20nm) of the extracellular domain; also contains a w+* marker.

(Scholz et al., 2017)
Allele components
Component
Use(s)
Tagged with
Tag:V5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The responses of Cirl3xCD4 mutant lch5 neurons in larvae to mechanical stimulation are reduced, compared to controls.

      (Scholz et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cirl3xCD4
      dCirl3xCD4
      (Scholz et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)