FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Atg9+tgr
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General Information
Symbol
Dmel\Atg9+tgr
Species
D. melanogaster
Name
FlyBase ID
FBal0336937
Feature type
allele
Associated gene
Dmel\Atg9
Associated Insertion(s)
Carried in Construct
P{gr-Atg9}
Key Links
Transgenic product class
genomic_DNA
(Wen et al., 2017)
wild_type
(Wen et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Wen et al., 2017)
wild_type
(Wen et al., 2017)
Mutagen
in vitro construct
(Wen et al., 2017)
Progenitor genotype
Carried in construct
P{gr-Atg9}
Cytology
Description

Genomic fragment containing the Atg9 transcription unit flanked by 1kb of both upstream and downstream sequence.

(Wen et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
Atg9
Encoded product / tool
Atg9
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Atg9+tgr rescues Atg9Gal4KO/Atg9d51

      (Wen et al., 2017)

      Atg9+tgr rescues Atg9d51

      (Wen et al., 2017)

      Atg9+tgr rescues Atg9Gal4KO

      (Wen et al., 2017)
      Comments

      The near lethality of Atg9Gal4KO/Atg9d51 transheterozygotes and of Atg9Gal4KO homozygotes is rescued by Atg9+tgr. Atg9+tgr also rescues the short lived phenotype, the defects in adult locomotion, the defects in the adult midgut (i.e. defects in length and thickness, in the visceral mesoderm layer, in the epithelial barrier function as shown by the abnormal permeability to a non-absorbable food dye, and in cell size), and the defects in autophagy (i.e. abnormal accumulation of ubiquitinated protein aggregates in adult thoracic muscles and both the developmental and starvation-induced autophagy in the larval and adult fat body, respectively) exhibited by Atg9Gal4KO/Atg9d51 transheterozygotes.

      (Wen et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Atg9+tgr
      Name Synonyms
      Secondary FlyBase IDs
        References (1)