FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fizdel
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General Information
Symbol
Dmel\fizdel
Species
D. melanogaster
Name
FlyBase ID
FBal0338044
Feature type
allele
Associated gene
Dmel\fiz
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Glaser-Schmitt and Parsch, 2018)
Mutagen
natural population
(Glaser-Schmitt and Parsch, 2018)
Progenitor genotype
Cytology
Description

A deletion introducing a frameshift that leads to a premature stop codon 232 amino acids into the fiz ORF.

(Glaser-Schmitt and Parsch, 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:14,907,919..14,907,950 [-]
Comment:

A 32 bp deletion in the fiz coding sequence leads to a frameshift and early translation termination after the addition of 20 novel amino acids.

(Glaser-Schmitt and Parsch, 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fizdel homozygotes exhibit significant increases in larval volume, adult weight, adult wing length (males and females) and area (female only), as well as in adult wing loading, as compared to controls.

      (Glaser-Schmitt and Parsch, 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG9509del
      (Glaser-Schmitt and Parsch, 2018)
      fizdel
      Name Synonyms
      Secondary FlyBase IDs
        References (1)