FB2026_02 , released June 18, 2026
Allele: Dmel\PGRP-SC2KO
Open Close
General Information
Symbol
Dmel\PGRP-SC2KO
Species
D. melanogaster
Name
FlyBase ID
FBal0338153
Feature type
allele
Associated gene
Dmel\PGRP-SC2
Associated Insertion(s)
TI{TI}PGRP-SC2KO
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Costechareyre et al., 2016)
Mutagen
gene targeting by homologous recombination
(Costechareyre et al., 2016)
Progenitor genotype
Associated Insertion(s)
TI{TI}PGRP-SC2KO
Cytology
Description

The entire PGRP-SC2 gene has been replaced by a loxP cassette containing a w+mW.hs marker.

(Costechareyre et al., 2016)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:8,716,950..8,717,695 [+]
Comment:

A 746bp region encompassing PGRP-SC2 is deleted and replaced with a loxP cassette containing a w+mW.hs marker.

(Costechareyre et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PGRP-SC2KO homozygous adults infected with Pseudomonas entomophila either by ingestion or by septic injury die significantly quicker than wild-type controls but their survival rate upon injury infection with Enterococcus faecalis is comparable to that of control flies.

      (Costechareyre et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PGRP-SC2KO
      Name Synonyms
      Secondary FlyBase IDs
        References (1)