FlyBase Allele Report: Dmel\ham[ΔCtBP.UAS]

General Information

Symbol

Dmel\ham^ΔCtBP.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0340315

Feature type

allele

Associated gene

Dmel\ham

Associated Insertion(s)

Carried in Construct

P{UAS-ham.ΔCtBP}

Key Links

Transgenic product class

missense_variant

(Endo et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Endo et al., 2011)

Mutagen

in vitro construct

(Endo et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-ham.ΔCtBP}

Cytology

Description

UAS regulatory sequences drive expression of ham with a mutation in the CtBP binding site.

(Endo et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

ham

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^sca-109-68

(Endo et al., 2011)

Phenotype Manifest In

notal microchaeta | adult stage, with Scer\GAL4^sca-109-68

(Endo et al., 2011)

tormogen cell | adult stage, with Scer\GAL4^sca-109-68

(Endo et al., 2011)

trichogen cell | adult stage | ectopic, with Scer\GAL4^sca-109-68

(Endo et al., 2011)

Detailed Description

Statement

Reference

Expressing ham^ΔCtBP.UAS under the control of Scer\GAL4^sca-109-68 results in disrupted notal microchaeta, with either a tormogen (socket) cell partially converted into an ectopic hair-like structure or two complete trichogen (hair) cells and no tormogen cell.

(Endo et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^sca-109-68, ham^ΔCtBP.UAS has visible | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Endo et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^sca-109-68, ham^ΔCtBP.UAS has notal microchaeta | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Endo et al., 2011)

Scer\GAL4^sca-109-68, ham^ΔCtBP.UAS has tormogen cell | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Endo et al., 2011)

Scer\GAL4^sca-109-68, ham^ΔCtBP.UAS has trichogen cell | ectopic | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Endo et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ham^ΔCtBP.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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