FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Klp54D3
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General Information
Symbol
Dmel\Klp54D3
Species
D. melanogaster
Name
FlyBase ID
FBal0341666
Feature type
allele
Associated gene
Dmel\Klp54D
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Radford et al., 2017)
Progenitor genotype
P{EP}G7530
(Radford et al., 2017)
Cytology
Description

Deletion of approximately 2.2kb, removing part of the 3' end of Klp54D (generated by imprecise excision of P{EP}G7530). A truncated protein (288 out of 725) amino acids may be produced, but half the kinesin motor domain is predicted to be missing.

(Radford et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:17,561,376..17,563,576 [+]
Comment:

Approximate boundaries of a ~2.2kb deletion resulting from the imprecise excision of P{EP}G7530), that extends from the middle of the Klp54D gene (after amino acid 288) to the site of the insertion.

(Radford et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Klp54D3 mutants show a low frequency of meiotic spindle asymmetry, but do not show obvious centromere asymmetry, homologous centromere orientation defects, karyosome compaction defects or X chromosome segregation defects, as compared to controls.

      (Radford et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Klp54D3 has meiotic spindle | oogenesis phenotype, non-suppressible by Klp61FHMS00552/Scer\GAL4VP16.mat.αTub67C

      (Radford et al., 2017)
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Klp54D3
      (Radford et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)