FB2026_02 , released June 18, 2026
Allele: Mmus\Ano6D430G-L.lexAop.Tag:FLAG
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General Information
Symbol
Mmus\Ano6D430G-L.lexAop.Tag:FLAG
Species
M. musculus
Name
FlyBase ID
FBal0343399
Feature type
allele
Associated gene
Mmus\Ano6
Associated Insertion(s)
Carried in Construct
PBac{lexAop-mAno6.D430G-L.FLAG}
Transgenic product class
gain_of_function_variant
(Sapar et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
gain_of_function_variant
(Sapar et al., 2018)
Mutagen
in vitro construct
(Sapar et al., 2018)
Progenitor genotype
Carried in construct
PBac{lexAop-mAno6.D430G-L.FLAG}
Cytology
Description

lexAop regulatory sequences drive expression of a hyperactive form of Mmus\Ano6. The protein is tagged with Tag:FLAG.

(Sapar et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
lexAop
Encoded product / tool
Mmus\Ano6
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Mmus\Ano6D430G-L.UAS.Tag:FLAG under the control of Ecol\lexAppk.PU leads to dendrite debris from class IV dendritic arborizing neurons being detected on the underlying epidermal cells and leads to a significant decrease in dendrite density and in dendrite field size, as compared to controls.

      (Sapar et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The combined tissue-specific knockout of CDC50 (CDC50sgRNA.U6+Spyo\Cas9ppk.PS) and expression of Mmus\Ano6D430G-L.lexAop.Tag:FLAG under the control of Ecol\lexAppk.PU leads to higher levels of dendrite debris from class IV dendritic arborizing neurons being detected on the underlying epidermal cells than upon either CDC50 knockout or Mmus\Ano6D430G-L.lexAop.Tag:FLAG expression; this phenotype is more severe upon heat shock. This "double mutant" background leads to significant vesicle shedding by class IV dendritic arborizing neurons compared to controls, which is suppressed by drprindel homozygosity.

      (Sapar et al., 2018)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mmus\Ano6D430G-L.lexAop.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (1)