FB2026_03 , released September 17, 2026
Allele: Dmel\mre11R563A
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General Information
Symbol
Dmel\mre11R563A
Species
D. melanogaster
Name
FlyBase ID
FBal0343426
Feature type
allele
Associated gene
Dmel\mre11
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-in gene targeting
(Yuan et al., 2018)
Progenitor genotype
Cytology
Description

The R563A amino acid replacement has been introduced into the endogenous mre11 gene.

(Yuan et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
2L:11,284,032..11,284,034 [+]
Reported amino acid change:

R563A

Comment:

The R563A amino acid replacement has been introduced into the endogenous mre11 gene by ends-in gene targeting.

(Yuan et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      As a result of being exposed to ionizing radiation at a dosage of 20, 30 or 40 Gy during third instar larval stage, mre11R563A homozygotes exhibit increased mortality and irradiation sensitivity compared to controls.

      After 10 Gy ionizing radiation, mitosis is almost completely blocked in mre11R563A third instar larval wing and eye discs similar to controls.

      (Yuan et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mre11R563A
      mre11R563A3-1D5
      (Yuan et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)