CRISPR construct designed to result in activation of a target gene when combined with a source of nuclease-dead Cas9 fused to a transcriptional activator domain. Constitutively expresses two sgRNAs that each target sequence upstream of the transcription start site of a gene of interest: sgRNA1 targets BBIP1 and CG8135, sgRNA2 targets BBIP1, CG8135 and CG9356.