FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Drer\ltkmne.UAS
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General Information
Symbol
Drer\ltkmne.UAS
Species
D. rerio
Name
FlyBase ID
FBal0343650
Feature type
allele
Associated gene
Drer\ltk
Associated Insertion(s)
Carried in Construct
P{UAS-ltk.mne}
Transgenic product class
gain_of_function_variant
(Fadeev et al., 2018)
missense_variant
(Fadeev et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
gain_of_function_variant
(Fadeev et al., 2018)
missense_variant
(Fadeev et al., 2018)
Mutagen
in vitro construct
(Fadeev et al., 2018)
Progenitor genotype
Carried in construct
P{UAS-ltk.mne}
Cytology
Description

UAS regulatory sequences drive expression of a gain-of-function form of Drer\ltk that carries the amino acid replacement F993I (analagous to the human ASLK-F1174 hotspot mutation seen in neuroblastoma patients).

(Fadeev et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Drer\ltk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neuroblastoma
      CEA
      (Fadeev et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Fadeev et al., 2018)

      Zebrafish gene.

      ALK:p.Phe1174Ile
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      ALK:p.Phe106Ile
      Associated human disease model(s)
      External database links
      ClinVar: ALK_217850
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Drer\ltkmne.UAS under the control of Scer\GAL4GMR.PF results in a rough eye phenotype.

      (Fadeev et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Drer\ltkmne.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)