FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pex21
Open Close
General Information
Symbol
Dmel\Pex21
Species
D. melanogaster
Name
FlyBase ID
FBal0344181
Feature type
allele
Associated gene
Dmel\Pex2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Wangler et al., 2017)
Progenitor genotype
P{EPg}Pex2HP35039
(Wangler et al., 2017)
Cytology
Description

7bp insertion within a 606bp deletion.

(Gomez et al., 2025)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  peroxisome biogenesis disorder 5A
      CEA
      (Wangler et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pex21/Df(3L)BSC376 transheterozygous adults show severely reduced activity and a progressive decrease in electroretinogram amplitude (observed in 4 weeks-old adults, but not in 2 days-old adults) under standard diet, as compared to controls. These mutants survive for less time than controls under either complete starvation or low-sugar diet.

      (Wangler et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pex21
      (Gomez et al., 2025)
      pex21
      (Wangler et al., 2025, Wangler et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)