FlyBase Allele Report: Rnor\Unc13a[UAS.cXa.EGFP]

General Information

Symbol

Rnor\Unc13a^UAS.cXa.EGFP

Species

R. norvegicus

Name

FlyBase ID

FBal0344211

Feature type

allele

Associated gene

Rnor\Unc13a

Associated Insertion(s)

Carried in Construct

P{UAS-rUnc13a.EGFP.X}

Transgenic product class

wild_type

(Xu et al., 2018)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Xu et al., 2018)

Mutagen

in vitro construct

(Xu et al., 2018)

Progenitor genotype

Carried in construct

P{UAS-rUnc13a.EGFP.X}

Cytology

Description

UASt regulatory sequences drive expression of Rnor\Unc13a coding sequences tagged with EGFP.

(Xu et al., 2018)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Rnor\Unc13a

Tagged with

EGFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates alcohol use disorder

modeled by unc-13^P84200

(Xu et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Rnor\Unc13a^UAS.cXa.EGFP/Scer\GAL4^elav.PLu is a suppressor | partially of chemical resistant | adult stage phenotype of unc-13^P84200

(Xu et al., 2018)

Rnor\Unc13a^UAS.cXa.EGFP/Scer\GAL4^elav.PLu is a suppressor | partially of abnormal locomotor behavior | adult stage | chemical conditional phenotype of unc-13^P84200

(Xu et al., 2018)

NOT Suppressor of

Statement

Reference

Rnor\Unc13a^UAS.cXa.EGFP/Scer\GAL4^elav.PLu is a non-suppressor of lethal - all die before end of P-stage | recessive phenotype of unc-13^P84200

(Xu et al., 2018)

Scer\GAL4^nSyb.PU/Rnor\Unc13a^UAS.cXa.EGFP is a non-suppressor of lethal - all die before end of P-stage | recessive phenotype of unc-13^P84200

(Xu et al., 2018)

Rnor\Unc13a^UAS.cXa.EGFP/Scer\GAL4^Tub.PU is a non-suppressor of lethal - all die before end of P-stage | recessive phenotype of unc-13^P84200

(Xu et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Rnor\Unc13a^UAS.cXa.EGFP under the control of Scer\GAL4^elav.PLu, in combination a Gal80[ts] transgene to restrict expression to the 48 hours prior to analysis, in unc-13^P84200/+ flies reduces their resistance to the sedative (loss of righting reflex) effects of ethanol.

(Xu et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Rnor\Unc13a^UAS.cXa.EGFP

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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