FB2026_02 , released June 18, 2026
Allele: Hsap\SERPINA1UAS.cYa
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General Information
Symbol
Hsap\SERPINA1UAS.cYa
Species
H. sapiens
Name
FlyBase ID
FBal0344462
Feature type
allele
Associated gene
Hsap\SERPINA1
Associated Insertion(s)
Carried in Construct
PBac{UAS-hAAT.Y}
Also Known As
UAS-hAAT
Key Links
Transgenic product class
cDNA
(Yuan et al., 2018)
wild_type
(Yuan et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Yuan et al., 2018)
wild_type
(Yuan et al., 2018)
Mutagen
in vitro construct
(Yuan et al., 2018)
Progenitor genotype
Carried in construct
PBac{UAS-hAAT.Y}
Cytology
Description

UASt regulatory sequences drive expression of a Hsap\SERPINA1 cDNA.

(Yuan et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\SERPINA1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Both the presence of the Hsap\SERPINA1UAS.cYa transgene alone or its expression under the control of Scer\GAL4Lsp2.PH lead to a significant increase in lifespan as compared to Scer\GAL4Lsp2.PH controls.

      Flies expressing Hsap\SERPINA1UAS.cYa under the control of either Scer\GAL4GSG6710 or Scer\GAL4GSG10751 have a significantly increased lifespan than controls, independent of driver activation with RU486. Induction of expression by RU486 treatment leads to a further increase in lifespan compared to non-induced controls for Scer\GAL4GSG6710, but not for Scer\GAL4GSG10751.

      (Yuan et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\SERPINA1UAS.cYa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)