FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cv-cCt.UAS.Tag:PH(PLCδ-Unk).Venus
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General Information
Symbol
Dmel\cv-cCt.UAS.Tag:PH(PLCδ-Unk).Venus
Species
D. melanogaster
Name
FlyBase ID
FBal0344570
Feature type
allele
Associated gene
Dmel\cv-c
Associated Insertion(s)
Carried in Construct
P{UAS-cv-c.Ct.PH.Venus}
Key Links
Transgenic product class
inframe_deletion
(Sotillos et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Sotillos et al., 2018)
Mutagen
in vitro construct
(Sotillos et al., 2018)
Progenitor genotype
Carried in construct
P{UAS-cv-c.Ct.PH.Venus}
Cytology
Description

UASt regulatory sequences drive expression of a C-terminal portion of cv-c (includes the GAP and START domains). The protein is tagged at the N-terminal end with a Tag:PH(PLCδ-Unk) membrane localization signal and at the C-terminal end with Venus.

(Sotillos et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
cv-c
Tagged with
Tag:PH(PLCδ-Unk)
Venus
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing cv-cCt.UAS.Tag:PH(PLCδ-Unk).Venus under the control of Scer\GAL4en.PU results in disrupted planar polarity in the embryonic epidermis, while expression under the control of Scer\GAL469B has no impact on salivary gland morphology in embryos.

      (Sotillos et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4ct.CtB/cv-cCt.UAS.Tag:PH(PLCδ-Unk).Venus partially rescues cv-c7/cv-cM62

      (Sotillos et al., 2018)
      Comments

      Expressing cv-cCt.UAS.Tag:PH(PLCδ-Unk).Venus under the control of Scer\GAL4ct.CtB rescues the Malpighian tubule elongation defect in a significant fraction of (but not all) cv-c7/cv-cM62 embryos.

      (Sotillos et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cv-cCt.UAS.Tag:PH(PLCδ-Unk).Venus
      Name Synonyms
      Secondary FlyBase IDs
        References (1)