UASt regulatory sequences drive expression of aop that has been mutated to increase the affinity of the aop SAM domain for self-association; the change is G96R. This mutation converts the wild-type aop residue to the equivalent residue found in the orthologous human ETV6 gene (HGNC:3495).
Expression from two copies of aopSY1.UAS under the control of Scer\GAL4GMR.PU induces a severe rough eye phenotype with severe loss of pigmentation; expression from one copy does not induce obvious defects.
