FB2026_02 , released June 18, 2026
Allele: Dmel\lin-281
Open Close
General Information
Symbol
Dmel\lin-281
Species
D. melanogaster
Name
FlyBase ID
FBal0346050
Feature type
allele
Associated gene
Dmel\lin-28
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lee et al., 2019)
Mutagen
P-element activity
(Lee et al., 2019)
Progenitor genotype
P{EP}lin-28EP915
(Lee et al., 2019)
Cytology
Description

Deletion that removes most of the exons of lin-28 (all except the first exon are deleted). The deletion ends immediately upstream of the downstream sif gene, and mRNA expression levels are similar to that of wild-type. Generated by imprecise excision of P{EP}lin-28EP915.

(Lee et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:5,656,370..5,657,910 [+]
Comment:

1541bp deletion resulting from the imprecise excision of P{EP}lin-28EP915 that removes most of the lin-28 coding region. The deletion ends immediately upstream of the downstream sif gene.

(Lee, 2020.2.7)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      lin-281/lin-281 embryos do not show any defects in the central nervous system (as shown by Mef2 and Pericardin immunostaining patterns) and hatch at comparable rates to controls.

      lin-281/lin-281 and lin-281/Df(3L)Exel6106 adult male and female flies do not show significant changes in body weight, as compared to controls.

      (Lee et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      lin-281/lin-281, pnrVX6/+ mutant embryos do not show any defects in the central nervous system (as shown by Mef2 and Pericardin immunostaining patterns), as compared to controls.

      (Lee et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      lin-281
      (Lee, 2020.2.7, Lee et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)