FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Prosβ5UAS.cNa
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General Information
Symbol
Dmel\Prosβ5UAS.cNa
Species
D. melanogaster
Name
UAS construct a of Nguyen
FlyBase ID
FBal0346669
Feature type
allele
Associated gene
Dmel\Prosβ5
Associated Insertion(s)
Carried in Construct
P{UAS-Prosβ5.N}
Key Links
Transgenic product class
wild_type
(Nguyen et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Nguyen et al., 2019)
Mutagen
in vitro construct
(Nguyen et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-Prosβ5.N}
Cytology
Description

UASt regulatory sequences drive expression of Prosβ5.

(Nguyen et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Prosβ5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression throughout adulthood of Prosβ5UAS.cNa under the control of Scer\GAL4da.Switch.PT, induced by mifepristone/RU486 in the diet, results in a significant increases in lifespan, food consumption and resistance to starvation, despite no effect on body weight or climbing ability, as compared to controls. There are no significant changes in survival to severe hyperoxia (>92% O[[2]]) or elevated temperature (37[o]C), as compared to controls.

      (Nguyen et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Prosβ5UAS.cNa
      Name Synonyms
      UAS construct a of Nguyen
      Secondary FlyBase IDs
        References (1)