FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\elgiCS.UAS.Tag:MYC,Tag:HA
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General Information
Symbol
Dmel\elgiCS.UAS.Tag:MYC,Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0347188
Feature type
allele
Associated gene
Dmel\elgi
Associated Insertion(s)
Carried in Construct
P{UAS-elgi.CS.Myc-HA}
Key Links
Transgenic product class
dominant_negative_variant
(Misra and Irvine, 2019)
missense_variant
(Misra and Irvine, 2019)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Misra and Irvine, 2019)
missense_variant
(Misra and Irvine, 2019)
Mutagen
in vitro construct
(Misra and Irvine, 2019)
Progenitor genotype
Carried in construct
P{UAS-elgi.CS.Myc-HA}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of elgi in which the two cysteines (C18 and C21) in the highly conserved RING domain have been mutated to serines. This results in a protein which cannot auto-ubiquitinate, and which shows dominant-negative activity (interfering with wild-type elgi function). The coding sequence is tagged with Tag:MYC and Tag:HA.

(Misra and Irvine, 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
elgi
Tagged with
Tag:HA
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of elgiCS.UAS.Tag:MYC,Tag:HA under the control of Scer\GAL4nub-AC-62 leads to slightly (but significantly) small and rounder wings, a significant decrease in cross vein spacing and a mild hair polarity defect in the proximal wing when compared to controls.

      (Misra and Irvine, 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      elgiCS.UAS.Tag:MYC,Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)