FB2026_02 , released June 18, 2026
Allele: Dmel\MED1O2
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General Information
Symbol
Dmel\MED1O2
Species
D. melanogaster
Name
FlyBase ID
FBal0347628
Feature type
allele
Associated gene
Dmel\MED1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Immarigeon et al., 2019)
Mutagen
ethyl methanesulfonate
(Immarigeon et al., 2019)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C1373T.

(Bourbon, 2019.6.12)

Amino acid replacement: Q408term.

(Bourbon, 2019.6.12)

Mutation creates a stop codon that interrupts the open reading frame of the three MED1 isoforms. (The location of the point mutation is a revision of data reported in FBrf0241861).

(Bourbon, 2019.6.12)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:21,633,009..21,633,009 [-]
Nucleotide change:

C21633009T

Amino acid change:

Q408term | MED1-PA; Q408term | MED1-PB; Q408term | MED1-PC

Reported amino acid change:

Q408term

(Bourbon, 2019.6.12)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MED1O2 homozygous mutant clones in the dorsal part of the wing disc (ap-Gal4>UAS-Flp) are often restricted to a single cell, while larger twin-spot wild-type clones are common. Larger mutant clones are retrieved when in a Minute background.

      Induction of MED1O2 mutant clones in a Minute background leads to mosaic adults displaying thoracic clefts and loss of dorsocentral mechanosensory macrochaetae, as compared to wild-type controls.

      (Immarigeon et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      MED1Δ9

      (Immarigeon et al., 2019)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MED1O2
      (Bourbon, 2019.6.12)
      Med1O2
      (Immarigeon et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)