FlyBase Allele Report: Dmel\Abi[4YE.UAS.Tag:HA]

General Information

Symbol

Dmel\Abi^{4YE.UAS.Tag:HA}

Species

D. melanogaster

Name

FlyBase ID

FBal0350337

Feature type

allele

Associated gene

Dmel\Abi

Associated Insertion(s)

Carried in Construct

P{UAS-Abi.4YE.HA}

Also Known As

UAS-HA-abi^4YE

Key Links

Transgenic product class

missense_variant

(Kim et al., 2019)

polypeptide_post_translational_processing_variant

(Kim et al., 2019)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Kim et al., 2019)

polypeptide_post_translational_processing_variant

(Kim et al., 2019)

Mutagen

in vitro construct

(Kim et al., 2019)

Progenitor genotype

Carried in construct

P{UAS-Abi.4YE.HA}

Cytology

Description

UASt regulatory sequences drive expression of a full-length Abi open reading frame (from the LD37010 cDNA clone), that has been mutated to carry 4 phosphomimetic amino acid substitutions: Y148E, Y155E, Y248E and Y285E. The coding sequence is tagged with Tag:HA.

(Kim et al., 2019)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Abi

Tagged with

Tag:HA

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing Abi^{4YE.UAS.Tag:HA} under the control of Scer\GAL4^elav-C155 has no effect on synaptic development at the NMJ of third instar larvae.

(Kim et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Abi^{4YE.UAS.Tag:HA} is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Abl⁴/Abl¹

(Kim et al., 2019)

NOT Suppressor of

Statement

Reference

Abi^{4YE.UAS.Tag:HA}, Scer\GAL4^elav-C155 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of SCAR^JF01599, Scer\GAL4^elav-C155

(Kim et al., 2019)

Abi^{4YE.UAS.Tag:HA}, Scer\GAL4^elav-C155 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Hem^JF03342, Scer\GAL4^elav-C155

(Kim et al., 2019)

Abi^{4YE.UAS.Tag:HA}, Scer\GAL4^elav-C155 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Rac1^N17.UAS, Scer\GAL4^elav-C155

(Kim et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Abi^{4YE.UAS.Tag:HA} is a suppressor of NMJ bouton | third instar larval stage phenotype of Abl⁴/Abl¹

(Kim et al., 2019)

Scer\GAL4^elav-C155/Abi^{4YE.UAS.Tag:HA} is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Abl⁴/Abl¹

(Kim et al., 2019)

NOT Suppressor of

Statement

Reference

Abi^{4YE.UAS.Tag:HA}, Scer\GAL4^elav-C155 is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of SCAR^JF01599, Scer\GAL4^elav-C155

(Kim et al., 2019)

Abi^{4YE.UAS.Tag:HA}, Scer\GAL4^elav-C155 is a non-suppressor of NMJ bouton | third instar larval stage phenotype of SCAR^JF01599, Scer\GAL4^elav-C155

(Kim et al., 2019)

Abi^{4YE.UAS.Tag:HA}, Scer\GAL4^elav-C155 is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Hem^JF03342, Scer\GAL4^elav-C155

(Kim et al., 2019)

Abi^{4YE.UAS.Tag:HA}, Scer\GAL4^elav-C155 is a non-suppressor of NMJ bouton | third instar larval stage phenotype of Hem^JF03342, Scer\GAL4^elav-C155

(Kim et al., 2019)

Abi^{4YE.UAS.Tag:HA}, Scer\GAL4^elav-C155 is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Rac1^N17.UAS, Scer\GAL4^elav-C155

(Kim et al., 2019)

Abi^{4YE.UAS.Tag:HA}, Scer\GAL4^elav-C155 is a non-suppressor of NMJ bouton | third instar larval stage phenotype of Rac1^N17.UAS, Scer\GAL4^elav-C155

(Kim et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^elav-C155/Abi^{4YE.UAS.Tag:HA} rescues Abi⁵/Df(3R)su(Hw)7

(Kim et al., 2019)

Comments

Expressing Abi^{4YE.UAS.Tag:HA} under the control of Scer\GAL4^elav-C155 rescues the supernumerary phenotype of both mature and satellite boutons at the NMNJ in Abi⁵/Df(3R)su(Hw)7 third instar larvae.

(Kim et al., 2019)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

97209

w¹¹¹⁸; P{UAS-Abi.4YE.HA}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Abi^{4YE.UAS.Tag:HA}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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