FB2026_02 , released June 18, 2026
Allele: Dmel\GstO1LL04542
Open Close
General Information
Symbol
Dmel\GstO1LL04542
Species
D. melanogaster
Name
FlyBase ID
FBal0351530
Feature type
allele
Associated gene
Dmel\GstO1
Associated Insertion(s)
PBac{SAstopDsRed}LL04542
Carried in Construct
Also Known As
GstO1PBac
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Choi et al., 2019)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{SAstopDsRed}LL04542
    Cytology
    Description

    P-element insertion in the second exon of GstO1.

    (Choi et al., 2019)
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{SAstopDsRed}
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  alcohol use disorder
        CEA
        (Choi et al., 2019)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        GstO1LL04542 adults do not show morphological defects but are significantly less resistant to ethanol sedation than controls: despite a normal hyper-excitability during early stages of exposure to ethanol, individuals stop climbing and succumb to sedation (loss of postural control) sooner than controls.

        (Choi et al., 2019)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        GstO1LL04542
        GstO1PBac
        (Hossain et al., 2023, Choi et al., 2019)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)