FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MCU1
Open Close
General Information
Symbol
Dmel\MCU1
Species
D. melanogaster
Name
FlyBase ID
FBal0351717
Feature type
allele
Associated gene
Dmel\MCU
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Tufi et al., 2019)
Mutagen
P-element activity
(Tufi et al., 2019)
Progenitor genotype
P{EPgy2}MCUEY08610
(Tufi et al., 2019)
Cytology
Description

Mobilization of P{EPgy2}EY08610, resulting in a deletion of 1,557 bp ( 3L:6550718-6552274 (Release 6)) removing the 5' end of MCU that includes the first three exons containing the start codon and mitochondrial targeting sequence common to most isoforms.

(Tufi et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:6,550,718..6,552,274 [+]
Comment:

A 1557bp deletion resulting from the imprecise excision of P{EPgy2}MCUEY08610 removes the translation start of MCU.

(Tufi et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MCU1 mutant adults have a slight, but significant reduction in climbing ability at 2 days, but not 20 days, after eclosion, compared to controls. There is no effect on mitochondrial morphology in the flight muscles or mitochondrial axonal transport, compared to controls.

      (Tufi et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      MCU1 is an enhancer of short lived phenotype of Tmbim5KO

      (Zhang et al., 2025)
      NOT Enhancer of
      Statement
      Reference

      MCU1 is a non-enhancer of lethal - all die before end of larval stage phenotype of MICU132

      (Tufi et al., 2019)
      NOT Suppressor of
      Statement
      Reference

      MCU1 is a non-suppressor of lethal - all die before end of larval stage phenotype of MICU132

      (Tufi et al., 2019)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      MCU1 is a non-enhancer of mitochondrion | larval stage phenotype of MICU132

      (Tufi et al., 2019)
      NOT Suppressor of
      Statement
      Reference

      MCU1 is a non-suppressor of mitochondrion | larval stage phenotype of MICU132

      (Tufi et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      MCU1 is rescued by MCUUAS.cTa/Scer\GAL4da.G32

      (Tufi et al., 2019)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MCU1
      (Zhang et al., 2025, Li et al., 2023, Rodríguez et al., 2020, Tufi et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)