FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\dapCRL4.UAS
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General Information
Symbol
Dmel\dapCRL4.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0351852
Feature type
allele
Associated gene
Dmel\dap
Associated Insertion(s)
Carried in Construct
PBac{UAS-dap.CRL4}
Key Links
Transgenic product class
missense_variant
(Bivik Stadler et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bivik Stadler et al., 2019)
Mutagen
in vitro construct
(Bivik Stadler et al., 2019)
Progenitor genotype
Carried in construct
PBac{UAS-dap.CRL4}
Cytology
Description

UAS regulatory sequences drive expression of the dap coding sequence (codon-optimized for Drosophila), in which conserved basic residues within the PIP degron sequence that flank the PCNA protein interaction domain and which have been shown to be important for the interaction with the CRL4[Cdt2] complex, have been mutated to Ala residues (change is RKR to AAA on both sides of the PCNA protein interaction domain).

(Bivik Stadler et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dap
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In individuals with injured gut at late L3W (by the expression of rprUAS.cCb), the expression of dapCRL4.UAS under the control of Scer\GAL4byn-Gal4 leads to decreased adult pyloric cell number.

      (Cohen et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dapCRL4.UAS
      dapCRL4
      (Bivik Stadler et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)