FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\osyΔMiM18
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General Information
Symbol
Dmel\osyΔMiM18
Species
D. melanogaster
Name
FlyBase ID
FBal0358591
Feature type
allele
Associated gene
Dmel\osy
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
minos activity
(Wang et al., 2020)
Progenitor genotype
Mi{ET1}osyMB00606
(Wang et al., 2020)
Cytology
Description

Imprecise excision of the Mi{ET1}osyMB00606 progenitor producing an insertion of 4 bp at the position of transposon insertion (in codon number 273), causing a frame-shift resulting in a stop codon soon downstream of the insertion site, in turn yielding a protein devoid of the ABC2 domain.

(Wang et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
3R:26,355,665..26,355,666 [+]
Comment:

Imprecise excision of the Mi{ET1}osyMB00606 progenitor producing an insertion of 4 bp at the position of transposon insertion (in codon number 273), causing a frame-shift resulting in a stop codon soon downstream of the insertion site, in turn yielding a protein devoid of the ABC2 domain.

Inserted_sequence:

NNNN

(Wang et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  autosomal recessive congenital ichthyosis
      CEA
      (Wang et al., 2020)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      osyΔMiM18 homozygous embryos and larvae have apparently normal morphology but larvae immobilize, flatten and die soon after hatching.

      Unlike controls, 1st instar larvae uptake Eosin Y at 40[o]C (but not at 25[o]C), indicating cuticle permeability despite a normal cuticle architecture, and their epidermal cells exhibit electron-lucid round structures, probably representing lipid droplet-like organelles, which are absent in controls.

      (Wang et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      osyΔMiM18
      (Wang et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)