FB2026_02 , released June 18, 2026
Allele: Dmel\upCD70
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General Information
Symbol
Dmel\upCD70
Species
D. melanogaster
Name
FlyBase ID
FBal0360096
Feature type
allele
Associated gene
Dmel\up
Associated Insertion(s)
TI{TI}upCD70
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
cre recombinase
(Cao et al., 2020)
Progenitor genotype
TI{TI}upCD70-RFP
(Cao et al., 2020)
Associated Insertion(s)
TI{TI}upCD70
Cytology
Description

The loxP cassette containing a Disc\RFP3xP3.cUa marker has been excised from TI{TI}upCD70-RFP, leaving a single loxP site in its place. The stop codon that was introduced into exon 11 of the endogenous up locus in TI{TI}upCD70-RFP is still present; this is expected to result in a truncated protein that lacks the last 70 amino acids including the C-terminal Glu-rich segment.

(Cao et al., 2020)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
complex_substitution
X:13,593,947..13,594,003 [-]
Comment:

This allele has an introduced stop codon in exon 11 of up. 57 bases of up sequence are deleted beyond the stop codon and a single loxP site is present in its place. This is expected to result in a truncated up protein missing the last 70 amino acids.

(Jin, 2020.6.29)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      upCD70/+ adults exhibit decreased average landing height when acute flight ability is assessed, lower endurance when it is tested by repetitive induction of climbing and decreased climbing velocity.

      upCD70/+ hearths are more sensitive to to the stress pacing (at 6 Hz for 30 s) while they are more resistant to 5-s episodes of high frequency pacing, with fewer fibrillation and arrest.

      upCD70/+ hearths and jump muscles exhibit longer resting sarcomeres. Also upCD70/+ jump muscles exhibit signs of Z-band streaming.

      (Cao et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TpnTCD70
      (Cao et al., 2020)
      upCD70
      (Jin, 2020.6.29)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)