FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\unc-4null
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General Information
Symbol
Dmel\unc-4null
Species
D. melanogaster
Name
FlyBase ID
FBal0360286
Feature type
allele
Associated gene
Dmel\unc-4
Associated Insertion(s)
TI{TI}unc-4null
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lacin et al., 2020)
Mutagen
FLPase
(Lacin et al., 2020)
Progenitor genotype
TI{TI}unc-4FRT
(Lacin et al., 2020)
Associated Insertion(s)
TI{TI}unc-4null
Cytology
Description

FLP-mediated removal of the 2nd and 3rd exons (from the progenitor TI{TI}unc-4FRT) generates unc-4 lacking the homeodomain. The Disc\RFP3xP3.cUa marker is also absent.

(Lacin et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults containing clones of unc-4null in their central nervous system and peripherial nervous system (via expression of Scer\FLP1UAS.cDa under the control of Scer\GAL4sca-537.4 in unc-4FRT flies) fail to fly; and exhibit erect wings, impaired grooming and climbing.

      Adults containing clones of unc-4null in their central nervous system (via expression of Scer\FLP1UAS.cDa under the control of Scer\GAL4dpn.EE in unc-4FRT flies) fail to fly; and exhibit erect wings and mild grooming defects.

      Adults containing clones of unc-4null in the chordotonal lineage and epithelial cells (via expression of Scer\FLP1UAS.cDa under the control of Scer\GAL4ato.3.6 in unc-4FRT flies) exhibit coordination defects in leg movements, defects in three-leg rubbing and walking (during which flies are slow and fell often).

      Adults containing clones of unc-4null in the 7B hemilineage (via expression of Scer\FLP1UAS.cDa under the control of both Hsap\RELAey-MI08729-Tp65AD.0 and Scer\GAL4Dbx-MI05316-TG4DBD.0 in unc-4FRT flies) impairs or interrupts take-off behavior.

      unc-4null clones of hemilineage 7B exhibit altered projections into the leg neuropils.

      (Lacin et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      unc-4null
      (Lacin et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)