FB2026_02 , released June 18, 2026
Allele: Dmel\Tgs1m1
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General Information
Symbol
Dmel\Tgs1m1
Species
D. melanogaster
Name
FlyBase ID
FBal0361149
Feature type
allele
Associated gene
Dmel\Tgs1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Maccallini et al., 2020)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    The point mutation within the moi coding sequence (the upstream open reading frame (ORF) of a dicistronic transcript that encodes both moi and Tgs1) also affects Tgs1 (the downstream ORF of the dicistronic transcript); in the presence of a transgene encoding moi[+], homozygotes for the mutation show substantially reduced levels of Tps1 protein compared to heterozygotes. FlyBase curator comment: the moi1 allele represents the effect of the point mutation on the moi ORF, while the Tgs1m1 allele represents the effect on Tgs1.

    (Maccallini et al., 2020)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Tgs1m1
        dTgs1m1
        (Maccallini et al., 2020)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)