FlyBase Allele Report: Dmel\Cmtr1[W231X]

General Information

Symbol

Dmel\Cmtr1^W231X

Species

D. melanogaster

Name

FlyBase ID

FBal0362281

Feature type

allele

Associated gene

Dmel\Cmtr1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Lee et al., 2020)

Mutagen

ethyl methanesulfonate

(Lee et al., 2020)

Progenitor genotype

Cytology

Description

A premature stop codon in Cmtr1, resulting in truncated protein that significantly impairs the catalytic 2'-O-MTase domain and thus likely represents a null allele of Cmtr1.

(Lee et al., 2020)

Amino acid replacement: W231term.

(Lee et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:4,099,849..4,099,849 [-]

Nucleotide change:

G4099848A

Amino acid change:

W231term | Cmtr1-PA; W231term | Cmtr1-PB

Reported amino acid change:

W231term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Lee et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Lee et al., 2020)

viable

(Lee et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Hsap\CMTR1^UAS.cLa/Scer\GAL4^GMR.PFa, Cmtr1^W231X/Cmtr1^W231X is a non-enhancer of abnormal eye color | semidominant phenotype of w^RNAi.GMR

(Lee et al., 2020)

Cmtr1^UAS.cLa/Scer\GAL4^GMR.PFa, Cmtr1^W231X/Cmtr1^W231X is a non-enhancer of abnormal eye color | semidominant phenotype of w^RNAi.GMR

(Lee et al., 2020)

Suppressor of

Statement

Reference

Cmtr1^W231X/Cmtr1^W231X is a suppressor | partially of visible phenotype of Csk^HMS02277, Scer\GAL4^GMR.PFa

(Lee et al., 2020)

Hsap\CMTR1^K239A.UAS/Scer\GAL4^GMR.PFa, Cmtr1^W231X/Cmtr1^W231X is a suppressor of abnormal eye color | semidominant phenotype of w^RNAi.GMR

(Lee et al., 2020)

Cmtr1^W231X/Cmtr1^W231X is a suppressor of abnormal eye color | semidominant phenotype of w^RNAi.GMR

(Lee et al., 2020)

Cmtr1^K179A.UAS/Scer\GAL4^GMR.PFa, Cmtr1^W231X/Cmtr1^W231X is a suppressor of abnormal eye color | semidominant phenotype of w^RNAi.GMR

(Lee et al., 2020)

NOT Suppressor of

Statement

Reference

Hsap\CMTR1^UAS.cLa/Scer\GAL4^GMR.PFa, Cmtr1^W231X/Cmtr1^W231X is a non-suppressor of abnormal eye color | semidominant phenotype of w^RNAi.GMR

(Lee et al., 2020)

Cmtr1^UAS.cLa/Scer\GAL4^GMR.PFa, Cmtr1^W231X/Cmtr1^W231X is a non-suppressor of abnormal eye color | semidominant phenotype of w^RNAi.GMR

(Lee et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cmtr1^W231X/Cmtr1^W231X is a suppressor | partially of eye phenotype of Csk^HMS02277, Scer\GAL4^GMR.PFa

(Lee et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cmtr1^W231X

dCMTR1^W231X

(Lee et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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