FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RpS26cKO
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General Information
Symbol
Dmel\RpS26cKO
Species
D. melanogaster
Name
FlyBase ID
FBal0367236
Feature type
allele
Associated gene
Dmel\RpS26
Associated Insertion(s)
TI{TI}RpS26cKO
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Recasens-Alvarez et al., 2021)
Progenitor genotype
TI{TI}RpS26attP-KO
(Recasens-Alvarez et al., 2021)
Associated Insertion(s)
TI{TI}RpS26cKO
Cytology
Description

Re-integration of sequence into the attP site present in TI{TI}RpS26attP-KO. The inserted sequence comprises: 1. an FRT cassette that contains the RpS26 sequence (exon 2) that was deleted in TI{TI}RpS26attP-KO (this reconstitutes a wild-type RpS26 locus) and a tub-mCherry marker, and 2. a loxP cassette that contains the Disc\RFPmCherry.3xP3 marker. This results in a conditional allele in which in RpS26 function can be disrupted by using FLP recombinase to excise the FRT cassette.

(Recasens-Alvarez et al., 2021)
Allele components
Component
Use(s)
Also carries
FRT
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Diamond-Blackfan anemia
      CEA
      (Recasens-Alvarez et al., 2021)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Conditional heterozygosity for RpS26cKO in the imaginal disc posterior region (hh-Gal4>FLP) leads to increased apoptosis only in the heterozygous region.

      (Recasens-Alvarez et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RPS26cKO
      (Recasens-Alvarez et al., 2021)
      RpS26cKO
      Name Synonyms
      Secondary FlyBase IDs
        References (1)