FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dis3l2GS6090
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General Information
Symbol
Dmel\Dis3l2GS6090
Species
D. melanogaster
Name
FlyBase ID
FBal0367259
Feature type
allele
Associated gene
Dmel\Dis3l2
Associated Insertion(s)
P{GSV3}GS6090
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV3}GS6090
    Cytology
    Description

    P{GSV3}GS6090 insertion 8bp upstream of Dis3l2 that can drive strong overexpression of Dis3l2.

    (Towler et al., 2020)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV3}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  Perlman syndrome
        CEA
        (Towler et al., 2020)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Expressing Dis3l2GS6090 under the control of Scer\GAL4en.PU leads to a small wing posterior compartment, and a decreased posterior/anterior. Wing discs also show a decreased posterior/anterior size ratio. Expression under the control of Scer\GAL469B results in wing discs with decreased mitotic index and decreased cell number.

        (Towler et al., 2020)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Dis3l2GS6090
        dis3L2OXP
        (Towler et al., 2020)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)