FlyBase Allele Report: SARS-CoV-2\nsp3[UAS.cZa]

General Information

Symbol

SARS-CoV-2\nsp3^UAS.cZa

Species

B. Severe acute respiratory syndrome coronavirus 2

Name

UAS construct of Zhu

FlyBase ID

FBal0367369

Feature type

allele

Associated gene

SARS-CoV-2\nsp3

Associated Insertion(s)

Carried in Construct

P{UAS-SARS-CoV-2-nsp3.Z}

Transgenic product class

wild_type

(Zhu et al., 2021)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Zhu et al., 2021)

Mutagen

in vitro construct

(Zhu et al., 2021)

Progenitor genotype

Carried in construct

P{UAS-SARS-CoV-2-nsp3.Z}

Cytology

Description

UASt regulatory sequences drive expression of the SARS-CoV-2\nsp3 coding sequence.

(Zhu et al., 2021)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

SARS-CoV-2\nsp3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Coronavirus infectious disease

CEA

(Zhu et al., 2022, Zhu et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | P-stage, with Scer\GAL4^GMR18D08

(Singh et al., 2024)

increased cell death | larval stage, with Scer\GAL4^GMR.PY

(Singh et al., 2024)

melanotic necrosis | adult stage | progressive, with Scer\GAL4^GMR.PY

(Singh et al., 2024)

partially lethal - majority die, with Scer\GAL4^αTub84B.PL

(Zhu et al., 2021)

short lived, with Scer\GAL4^αTub84B.PL

(Zhu et al., 2021)

visible | adult stage | progressive, with Scer\GAL4^GMR.PY

(Singh et al., 2024)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PY

(Singh et al., 2024)

eye disc | larval stage, with Scer\GAL4^GMR.PY

(Singh et al., 2024)

eye photoreceptor cell | P-stage, with Scer\GAL4^GMR18D08

(Singh et al., 2024)

ommatidium | adult stage, with Scer\GAL4^GMR.PY

(Singh et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

SARS-CoV-2\nsp3^UAS.cZa, Scer\GAL4^GMR.PY is an enhancer of visible | adult stage phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PY

(Singh et al., 2024)

SARS-CoV-2\nsp3^UAS.cZa, Scer\GAL4^GMR.PY is an enhancer of abnormal neuroanatomy | larval stage phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PY

(Singh et al., 2024)

SARS-CoV-2\nsp3^UAS.cZa, Scer\GAL4^GMR.PY is an enhancer of decreased size | adult stage phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PY

(Singh et al., 2024)

SARS-CoV-2\nsp3^UAS.cZa, Scer\GAL4^GMR.PY is an enhancer of increased cell death | larval stage phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PY

(Singh et al., 2024)

Other

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, SARS-CoV-2\nsp3^UAS.cZa, Scer\GAL4^GMR.PY has melanotic necrosis | adult stage phenotype

(Singh et al., 2024)

Phenotype Manifest In

Enhancer of

Statement

Reference

SARS-CoV-2\nsp3^UAS.cZa, Scer\GAL4^GMR.PY is an enhancer of eye phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PY

(Singh et al., 2024)

SARS-CoV-2\nsp3^UAS.cZa, Scer\GAL4^GMR.PY is an enhancer of eye photoreceptor cell | larval stage phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PY

(Singh et al., 2024)

SARS-CoV-2\nsp3^UAS.cZa, Scer\GAL4^GMR.PY is an enhancer of eye disc | larval stage phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PY

(Singh et al., 2024)

Other

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, SARS-CoV-2\nsp3^UAS.cZa, Scer\GAL4^GMR.PY has eye phenotype

(Singh et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

SARS-CoV-2\nsp3^UAS.cZa

Name Synonyms

UAS construct of Zhu

Secondary FlyBase IDs

References (4)

Report Sections

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