FlyBase Allele Report: SARS-CoV-2\ORF6[UAS.cZa]

General Information

Symbol

SARS-CoV-2\ORF6^UAS.cZa

Species

B. Severe acute respiratory syndrome coronavirus 2

Name

UAS construct of Zhu

FlyBase ID

FBal0367373

Feature type

allele

Associated gene

SARS-CoV-2\ORF6

Associated Insertion(s)

Carried in Construct

P{UAS-SARS-CoV-2-ORF6.Z}

Transgenic product class

wild_type

(Zhu et al., 2021)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Zhu et al., 2021)

Mutagen

in vitro construct

(Zhu et al., 2021)

Progenitor genotype

Carried in construct

P{UAS-SARS-CoV-2-ORF6.Z}

Cytology

Description

UASt regulatory sequences drive expression of the SARS-CoV-2\ORF6 coding sequence.

(Zhu et al., 2021)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

SARS-CoV-2\ORF6

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Coronavirus infectious disease

CEA

(Zhu et al., 2022, Zhu et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^αTub84B.PL

(Zhu et al., 2021)

partially lethal - majority die, with Scer\GAL4^αTub84B.PL

(Zhu et al., 2021)

short lived, with Scer\GAL4^αTub84B.PL

(Zhu et al., 2021)

visible | adult stage, with Scer\GAL4^GMR.PY

(Singh et al., 2024)

visible | adult stage, with Scer\GAL4^αTub84B.PL

(Zhu et al., 2021)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PY

(Singh et al., 2024)

indirect flight muscle cell | adult stage, with Scer\GAL4^αTub84B.PL

(Zhu et al., 2021)

larval tracheal system | larval stage, with Scer\GAL4^αTub84B.PL

(Zhu et al., 2021)

mitochondrion | adult stage | decreased number, with Scer\GAL4^αTub84B.PL

(Zhu et al., 2021)

wing, with Scer\GAL4^αTub84B.PL

(Zhu et al., 2021)

Detailed Description

Statement

Reference

The expression of SARS-CoV-2\ORF6^UAS.cZa under the control of Scer\GAL4^αTub84B.PL leads to larvae with fewer tracheal branches.

Adults expressing SARS-CoV-2\ORF6^UAS.cZa under the control of Scer\GAL4^αTub84B.PL display decreased climbing activity and held-up wings; indirect flight muscles present fewer mitochondria.

(Zhu et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

SARS-CoV-2\ORF6^UAS.cZa

Name Synonyms

UAS construct of Zhu

Secondary FlyBase IDs

References (5)

Report Sections

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