FB2026_03 , released September 17, 2026
Allele: Dmel\CG4743R166Q
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General Information
Symbol
Dmel\CG4743R166Q
Species
D. melanogaster
Name
FlyBase ID
FBal0368037
Feature type
allele
Associated gene
Dmel\CG4743
Associated Insertion(s)
TI{TI}CG4743R166Q
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Schober and Wredenberg, 2021.5.25)
Progenitor genotype
TI{TI}CG4743KO
(Schober and Wredenberg, 2021.5.25)
Associated Insertion(s)
TI{TI}CG4743R166Q
Cytology
Description

Re-integration of sequence using the attP site present in TI{TI}CG4743KO (after first removing the loxP cassette), reconstituting a mutant CG4743 transcription unit at the native locus; contains a R166Q amino acid substitution (this mutation is equivalent to a variant with clinical significance in the orthologous human gene). In addition, a loxP cassette containing a wGMR.PHb marker has been inserted downstream of the CG4743 coding sequence and the attP site has been converted into an attR site (this is located upstream of the CG4743 coding sequence).

(Schober and Wredenberg, 2021.5.25)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Schober and Wredenberg, 2021.5.25)

      Disease model in flies has not been developed.

      (FlyBase curators, 2019-)
      SLC25A26:p.Arg142Gln
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      SLC25A26:p.Arg54Gln
      Associated human disease model(s)
        External database links
        Comments concerning this variant
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        CG4743R166Q
        Name Synonyms
        Secondary FlyBase IDs
          References (2)