FB2026_02 , released June 18, 2026
Allele: Dmel\LU6.sgRNA.DE1
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General Information
Symbol
Dmel\LU6.sgRNA.DE1
Species
D. melanogaster
Name
FlyBase ID
FBal0368845
Feature type
allele
Associated gene
Dmel\L
Associated Insertion(s)
Carried in Construct
P{U6-L.sgRNA.DE1}
Key Links
Transgenic product class
sgRNA
(Son and Choi, 2020)
Mutagen
Nature of the Allele
Transgenic product class
sgRNA
(Son and Choi, 2020)
Mutagen
in vitro construct
(Son and Choi, 2020)
Progenitor genotype
Carried in construct
P{U6-L.sgRNA.DE1}
Cytology
Description

A U6 promoter drives expression of 2 sgRNAs (5'-tggatatatctttcggctag-agg-3' and 5'-agaccaaaacctgtggggca-agg-3'), both of which target intron 2 of the L-RC isoform (the two target sites flank the location of the opus{}Mohr insertion that is present in a number of dominant L mutant chromosomes).

(Son and Choi, 2020)
Allele components
Component
Use(s)
Encoded product / tool
L
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of LU6.sgRNA.DE1 under the control of Spyo\Cas9Act5C.cPa in a L2/+ background variably suppresses the L2/+ eye phenotype.

      (Son and Choi, 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      LU6.sgRNA.DE1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)