FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tbc1d2246C
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General Information
Symbol
Dmel\Tbc1d2246C
Species
D. melanogaster
Name
FlyBase ID
FBal0369465
Feature type
allele
Associated gene
Dmel\Tbc1d22
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W392term.

    (Duan et al., 2021)

    Nucleotide substitution: A?G.

    (Duan et al., 2021)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:21,104,069..21,104,069 [+]
    Nucleotide change:

    G21104069A

    Reported nucleotide change:

    G?A

    Amino acid change:

    W392term | Tbc1d22-PA

    Reported amino acid change:

    W392term

    Comment:

    Nonsense mutation (TGG to TGA) at Trp codon.

    (Duan et al., 2021)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Tbc1d2246C homozygous eye clones display more and larger lipid droplets in adult retina glial and photoreceptor cells of 1-day old adults; the glia cell layer in 15-day- and 30-day-old flies is thinner than that in 1-day-old flies.

        (Duan et al., 2021)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Tbc1d2246C/Tbc1d2270A is rescued by Tbc1d22Tag:HA

        (Duan et al., 2021)
        Partially rescued by

        Tbc1d2246C is partially rescued by Tbc1d22Tag:HA

        (Duan et al., 2021)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        3R46C
        (Duan et al., 2021)
        Tbc1d2246C
        Name Synonyms
        Secondary FlyBase IDs
          References (1)