FlyBase Allele Report: Dmel\Tssk[K60M]

The full Tssk gene locus with a K60M mutation in the ATP-binding site of the S_TKc kinase domain to render it kinase dead, has been cloned into the pUAST-attB vector.

(Zhang et al., 2023)

Allele components

Component

Use(s)

Regulatory region(s)

Tssk

Encoded product / tool

Tssk

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile, with Tssk^KO

(Zhang et al., 2023)

Phenotype Manifest In

cystic bulge, with Tssk^KO

(Zhang et al., 2023)

male germ cell nucleus, with Tssk^KO

(Zhang et al., 2023)

spermatid, with Tssk^KO

(Zhang et al., 2023)

spermatozoon | absent, with Tssk^KO

(Zhang et al., 2023)

sperm flagellum, with Tssk^KO

(Zhang et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Tssk^K60M

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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