FB2026_03 , released September 17, 2026
Allele: Dmel\MayoNRS-ΔS3-lexA
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General Information
Symbol
Dmel\MayoNRS-ΔS3-lexA
Species
D. melanogaster
Name
FlyBase ID
FBal0391600
Feature type
allele
Associated gene
Dmel\Mayo
Associated Insertion(s)
TI{TI}MayoNRS-ΔS3-lexA
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Scholz et al., 2023)
Progenitor genotype
Associated Insertion(s)
TI{TI}MayoNRS-ΔS3-lexA
Cytology
Description

A control transgene in which a sequence cassette encoding a fusion protein composed of 1. a Tag:HA epitope, 2. the complete Mayo extracellular region (including the autoproteolytically active GAIN domain with its GPCR proteolysis site (GPS)), 3. the juxta- and transmembrane segment of N (JTS) in which the γ-secretase S3 cleavage site has been mutated, 4. the lexA::VP16 driver and 5. three copies of the Tag:V5 epitope has been inserted into the Mayo locus, resulting in expression of the fusion protein under the control of endogenous Mayo regulatory sequences. The mutation in the S3 cleavage site prevents release of the lexA::VP16 driver upon activation of Mayo.

(Scholz et al., 2023)
Allele components
Component
Use(s)
Tagged with
Tag:HA
Tag:V5
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MayoNRS-ΔS3-lexA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)