FB2026_02 , released June 18, 2026
Allele: Dmel\mab-21F58L.UAS.Tag:HA
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General Information
Symbol
Dmel\mab-21F58L.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0392294
Feature type
allele
Associated gene
Dmel\mab-21
Associated Insertion(s)
Carried in Construct
M{UAS-mab-21.F58L.HA}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Meng et al., 2023)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Meng et al., 2023)
Mutagen
in vitro construct
(Meng et al., 2023)
Progenitor genotype
Carried in construct
M{UAS-mab-21.F58L.HA}
Cytology
Description

UASt regulatory sequences drive expression of mab-21 cDNA (RE21580) containing the human disease-relevant F58L mutation, tagged with 3xTag:HA.

(Meng et al., 2023)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mab-21
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:6,012,651..6,012,651 [-]
Nucleotide change:

T6012651C

Amino acid change:

F58L | mab-21-PA

Reported amino acid change:

F58L

Comment:

Analogous mutation in human MAB21L1 implicated in congenital eye defects; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Meng et al., 2023)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  microphthalmia
      CEA
      (Meng et al., 2023)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Meng et al., 2023)
      MAB21L1:p.Phe52Leu
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
        External database links
        Comments concerning this variant

        Disease model in flies has not been developed.

        (FlyBase curators, 2019-)
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        mab-21F58L.UAS.Tag:HA
        Name Synonyms
        Secondary FlyBase IDs
          References (2)