FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\TREX1ΔExo.RVCL.UAS.MYC
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General Information
Symbol
Hsap\TREX1ΔExo.RVCL.UAS.MYC
Species
H. sapiens
Name
FlyBase ID
FBal0403147
Feature type
allele
Associated gene
Hsap\TREX1
Associated Insertion(s)
Carried in Construct
M{UAS-hTREX1.ΔExo.RVCL.MYC}
Key Links
Transgenic product class
missense_variant
(Chauvin et al., 2024)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Chauvin et al., 2024)
Mutagen
in vitro construct
(Chauvin et al., 2024)
Progenitor genotype
Carried in construct
M{UAS-hTREX1.ΔExo.RVCL.MYC}
Cytology
Description

20xUAS regulatory sequences drive expression of enzymatically inactive (R62A), terminally truncated Hsap\TREX1 carrying the V235Gfs mutation (associated with retinal vasculopathy with cerebral leukoencephalopathy in humans). Tagged at the N-terminus with Tag:MYC.

(Chauvin et al., 2024)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\TREX1
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Chauvin et al., 2024)

      This combination of mutational lesions not found in human.

      (FlyBase curators, 2019-)
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\TREX1ΔExo.RVCL.UAS.MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)