FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mt:ATPase6mt.5Smt
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General Information
Symbol
Dmel\mt:ATPase6mt.5Smt
Species
D. melanogaster
Name
FlyBase ID
FBal0405510
Feature type
allele
Associated gene
Dmel\mt:ATPase6
Associated Insertion(s)
Carried in Construct
P{mt-5Smt-mt:ATPase6}
Key Links
Transgenic product class
wild_type
(Markantone et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Markantone et al., 2018)
Mutagen
in vitro construct
(Markantone et al., 2018)
Progenitor genotype
Carried in construct
P{mt-5Smt-mt:ATPase6}
Cytology
Description

A RNA polymerase III promoter drives expression of a transcription unit composed of a non-coding leader (NCL) sequence (from the major mitochondrial 5S rRNA isoform encoded by the 5SrRNA gene), a translation initiation sequence and the mt:ATPase6 open reading frame (ORF). The ORF has been engineered for mitochondrial translation and a cytosolic stop codon (that encodes the Trp residue in mitochondria) has been introduced at codon 20. The presence of the NCL sequence targets the RNA to the mitochondrion. The presence of the early cytosolic stop codon is designed to prevent expression of the full-length mt:ATPase6 ORF in the cytosol, while allowing expression of the full-length ORF in the mitochondrion.

(Markantone et al., 2018)
Allele components
Component
Use(s)
Encoded product / tool
mt:ATPase6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  mitochondrial metabolism disease
      modeled by mt:ATPase61
      (Markantone et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mt:ATPase6mt.5Smt
      Name Synonyms
      Secondary FlyBase IDs
        References (1)