FB2026_02 , released June 18, 2026
Allele: Dmel\Sgip1W694G.UAS.EGFP
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General Information
Symbol
Dmel\Sgip1W694G.UAS.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0406105
Feature type
allele
Associated gene
Dmel\Sgip1
Associated Insertion(s)
Carried in Construct
P{UAS-Sgip1.W694G.EGFP}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Decet et al., 2024)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Decet et al., 2024)
Mutagen
in vitro construct
(Decet et al., 2024)
Progenitor genotype
Carried in construct
P{UAS-Sgip1.W694G.EGFP}
Cytology
Description

UASt regulatory sequences drive expression of Sgip1 cDNA carrying the human disease-relevant W694G mutation; tagged at the N-terminal with EGFP.

(Decet et al., 2024)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Sgip1
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,525,993..9,525,993 [+]
Nucleotide change:

T9525993G

Reported nucleotide change:

T?G

Amino acid change:

W975G | Sgip1-PA; W1062G | Sgip1-PC; W975G | Sgip1-PE; W1062G | Sgip1-PF; W1003G | Sgip1-PG

Reported amino acid change:

W1003G

Comment:

Analogous mutation in human SGIP1 implicated in Parkinson disease, early-onset (postulated), SGIP1-related; mutation carried on in vitro construct.

(Decet et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  early-onset Parkinson's disease
      CEA
      (Decet et al., 2024)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Decet et al., 2024)
      SGIP1:p.Trp694Gly
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      SGIP1:p.Trp697Gly
      SGIP1:p.Trp725Gly
      SGIP1:p.Trp495Gly
      SGIP1:p.Trp716Gly
      Associated human disease model(s)
      External database links
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Sgip1W694G.UAS.EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (2)