FlyBase Allele Report: Dmel\slmo[RNAi.UAS.1]

General Information

Symbol

Dmel\slmo^RNAi.UAS.1

Species

D. melanogaster

Name

FlyBase ID

FBal0406918

Feature type

allele

Associated gene

Dmel\slmo

Associated Insertion(s)

Carried in Construct

M{UAS-slmo.RNAi.1}

Key Links

Transgenic product class

RNAi_reagent

(Zhao et al., 2024)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Zhao et al., 2024)

Mutagen

in vitro construct

(Zhao et al., 2024)

Progenitor genotype

Carried in construct

M{UAS-slmo.RNAi.1}

Cytology

Description

UAS regulates expression of a shRNA sequence targeting slmo, generated using the pNP system.

(Zhao et al., 2024)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

slmo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.long

(Zhao et al., 2024)

abnormal neurophysiology | adult stage, with Scer\GAL4^GMR.long

(Zhao et al., 2024)

decreased size | adult stage, with Scer\GAL4^Mhc.PU

(Zhao et al., 2024)

Phenotype Manifest In

indirect flight muscle | adult stage, with Scer\GAL4^Mhc.PU

(Zhao et al., 2024)

mitochondrial crista | adult stage, with Scer\GAL4^Mhc.PU

(Zhao et al., 2024)

mitochondrion | adult stage, with Scer\GAL4^Mhc.PU

(Zhao et al., 2024)

retina | adult stage, with Scer\GAL4^GMR.long

(Zhao et al., 2024)

rhabdomere of eye photoreceptor cell | adult stage, with Scer\GAL4^GMR.long

(Zhao et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^GMR.long, slmo^RNAi.UAS.1 has abnormal neurophysiology | adult stage phenotype, suppressible by Hsap\PRELID3B^UAS.cZa, Scer\GAL4^GMR.long

(Zhao et al., 2024)

NOT suppressed by

Statement

Reference

Scer\GAL4^Mhc.PU, slmo^RNAi.UAS.1 has decreased size | adult stage phenotype, non-suppressible by Pss^UAS.cWa, Scer\GAL4^Mhc.PU

(Zhao et al., 2024)

Scer\GAL4^GMR.long, slmo^RNAi.UAS.1 has abnormal neurophysiology | adult stage phenotype, non-suppressible by Hsap\PRELID3A^UAS.cZa, Scer\GAL4^GMR.long

(Zhao et al., 2024)

Scer\GAL4^GMR.long, slmo^RNAi.UAS.1 has abnormal neurophysiology | adult stage phenotype, non-suppressible by Hsap\PRELID1^UAS.cZa, Scer\GAL4^GMR.long

(Zhao et al., 2024)

Other

Statement

Reference

Pect^RNAi.UAS.5, Pisd^trp.PW, Scer\GAL4^GMR.long, slmo^RNAi.UAS.1 has abnormal neuroanatomy | adult stage phenotype

(Zhao et al., 2024)

Pect^RNAi.UAS.5, Pisd^trp.PW, Scer\GAL4^GMR.long, slmo^RNAi.UAS.1 has abnormal neurophysiology | adult stage phenotype

(Zhao et al., 2024)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^GMR.long, slmo^RNAi.UAS.1 has retina | adult stage phenotype, suppressible by Hsap\PRELID3B^UAS.cZa, Scer\GAL4^GMR.long

(Zhao et al., 2024)

NOT suppressed by

Statement

Reference

Scer\GAL4^Mhc.PU, slmo^RNAi.UAS.1 has indirect flight muscle | adult stage phenotype, non-suppressible by Pss^UAS.cWa, Scer\GAL4^Mhc.PU

(Zhao et al., 2024)

Scer\GAL4^Mhc.PU, slmo^RNAi.UAS.1 has mitochondrion | adult stage phenotype, non-suppressible by Pss^UAS.cWa, Scer\GAL4^Mhc.PU

(Zhao et al., 2024)

Scer\GAL4^GMR.long, slmo^RNAi.UAS.1 has retina | adult stage phenotype, non-suppressible by Hsap\PRELID3A^UAS.cZa, Scer\GAL4^GMR.long

(Zhao et al., 2024)

Scer\GAL4^GMR.long, slmo^RNAi.UAS.1 has retina | adult stage phenotype, non-suppressible by Hsap\PRELID1^UAS.cZa, Scer\GAL4^GMR.long

(Zhao et al., 2024)

Other

Statement

Reference

Pect^RNAi.UAS.5, Pisd^trp.PW, Scer\GAL4^GMR.long, slmo^RNAi.UAS.1 has retina | adult stage phenotype

(Zhao et al., 2024)

Pect^RNAi.UAS.5, Pisd^trp.PW, Scer\GAL4^GMR.long, slmo^RNAi.UAS.1 has rhabdomere of eye photoreceptor cell | adult stage | decreased number phenotype

(Zhao et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

slmo^RNAi.UAS.1 is rescued by slmo^R1.UAS/Scer\GAL4^GMR.long

(Zhao et al., 2024)

slmo^RNAi.UAS.1 is rescued by slmo^R1.UAS/Scer\GAL4^Mhc.PU

(Zhao et al., 2024)

slmo^RNAi.UAS.1 is rescued by slmo^R1.Ubi.EGFP

(Zhao et al., 2024)

slmo^RNAi.UAS.1 is rescued by slmo^R1.da

(Zhao et al., 2024)

Not rescued by

slmo^RNAi.UAS.1 is not rescued by slmo^N150A.R1.da

(Zhao et al., 2024)

slmo^RNAi.UAS.1 is not rescued by slmo^T93A.R1.da

(Zhao et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

slmo^RNAi.UAS.1

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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