FlyBase Allele Report: Dmel\Mtx2[EGFP]

General Information

Symbol

Dmel\Mtx2^EGFP

Species

D. melanogaster

Name

FlyBase ID

FBal0407315

Feature type

allele

Associated gene

Dmel\Mtx2

Associated Insertion(s)

TI{TI}Mtx2^EGFP

Carried in Construct

Key Links

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Zhang et al., 2025)

Progenitor genotype

Associated Insertion(s)

TI{TI}Mtx2^EGFP

Cytology

Description

A knock-in allele in which the Mtx2 coding sequence has been replaced with a Mtx2-EGFP fusion sequence (tagged at the C-terminus), flanked by FRT sites.

(Zhang et al., 2025)

Allele components

Component

Use(s)

Tagged with

EGFP

green fluorescent protein

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage (with Mtx2¹), with Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

decreased rate of adult locomotory behavior | progressive (with Mtx2^ΔDsRed), with Scer\FLP1^UAS.cUa, Scer\GAL4^GMR57C10

(Zhang et al., 2025)

fertile

(Zhang et al., 2025)

lethal - all die during pharate adult stage (with Mtx2¹), with Scer\FLP1^UAS.cUa, Scer\GAL4^Tub.PU

(Zhang et al., 2025)

short lived (with Mtx2^ΔDsRed), with Scer\FLP1^UAS.cUa, Scer\GAL4^GMR57C10

(Zhang et al., 2025)

viable

(Zhang et al., 2025)

Phenotype Manifest In

adult antennal lobe (with Mtx2¹), with Scer\FLP1^UAS.cUa, Scer\GAL4^GMR57C10

(Zhang et al., 2025)

adult mushroom body (with Mtx2¹), with Scer\FLP1^UAS.cUa, Scer\GAL4^GMR57C10

(Zhang et al., 2025)

axon | adult stage (with Mtx2¹), with Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

gustatory receptor neuron of the wing (with Mtx2¹), with Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

mitochondrion | adult stage (with Mtx2¹), with Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

mitochondrion | adult stage (with Mtx2¹), with Scer\FLP1^UAS.cUa, Scer\GAL4^GMR57C10

(Zhang et al., 2025)

wing sensillum | increased number (with Mtx2¹), with Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

CG5662¹, Mtx2^EGFP/Mtx2^ΔDsRed, Scer\FLP1^UAS.cUa, Scer\GAL4^GMR57C10 has viable phenotype

(Zhang et al., 2025)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Mtx2^EGFP/Mtx2¹, Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07 has gustatory receptor neuron of the wing phenotype, non-enhanceable by CG5662¹

(Zhang et al., 2025)

Mtx2^EGFP/Mtx2¹, Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07 has mitochondrion | adult stage phenotype, non-enhanceable by CG5662¹

(Zhang et al., 2025)

Mtx2^EGFP/Mtx2¹, Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07 has axon | adult stage phenotype, non-enhanceable by CG5662¹

(Zhang et al., 2025)

NOT suppressed by

Statement

Reference

Mtx2^EGFP/Mtx2¹, Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07 has gustatory receptor neuron of the wing phenotype, non-suppressible by CG5662¹

(Zhang et al., 2025)

Mtx2^EGFP/Mtx2¹, Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07 has mitochondrion | adult stage phenotype, non-suppressible by CG5662¹

(Zhang et al., 2025)

Mtx2^EGFP/Mtx2¹, Scer\FLP1^UAS.cUa, Scer\GAL4^GMR15B07 has axon | adult stage phenotype, non-suppressible by CG5662¹

(Zhang et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Mtx2^EGFP/Mtx2¹ is rescued by Scer\GAL4^Tub.PU/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Mtx2^EGFP/Mtx2¹ is rescued by Scer\GAL4^GMR15B07/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Mtx2^EGFP/Mtx2^ΔDsRed is rescued by Scer\GAL4^GMR57C10/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mtx2^EGFP

dMtx2^EGFP

(Zhang et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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