FlyBase Allele Report: Hsap\LRRK2[G2019S.UAS.GFP]

General Information

Symbol

Hsap\LRRK2^{G2019S.UAS.GFP}

Species

H. sapiens

Name

FlyBase ID

FBal0413428

Feature type

allele

Associated gene

Hsap\LRRK2

Associated Insertion(s)

Carried in Construct

P{UAS-hLRRK2.G2019S.GFP}

Key Links

Transgenic product class

missense_variant

(Chua et al., 2020)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Chua et al., 2020)

Mutagen

in vitro construct

(Chua et al., 2020)

Progenitor genotype

Carried in construct

P{UAS-hLRRK2.G2019S.GFP}

Cytology

Description

UASt regulatory sequences drive expression of Hsap\LRRK2 cDNA carrying the G2019S mutation, tagged with GFP at the C-terminal.

(Chua et al., 2020)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\LRRK2

Tagged with

GFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage, with Scer\GAL4^Ddc.PU

(Chua et al., 2020)

decreased rate of adult locomotory behavior, with Scer\GAL4^Ddc.PU

(Chua et al., 2020)

short lived, with Scer\GAL4^Ddc.PU

(Chua et al., 2020)

Phenotype Manifest In

adult dopaminergic neuron | decreased number, with Scer\GAL4^Ddc.PU

(Chua et al., 2020)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\LRRK2^{G2019S.UAS.GFP}, Scer\GAL4^Ddc.PU has decreased cell number | adult stage phenotype, suppressible | partially by Hsap\PRDX2^UAS.cCa, Scer\GAL4^Ddc.PU

(Chua et al., 2020)

Hsap\LRRK2^{G2019S.UAS.GFP}, Scer\GAL4^Ddc.PU has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Hsap\PRDX2^UAS.cCa, Scer\GAL4^Ddc.PU

(Chua et al., 2020)

Hsap\LRRK2^{G2019S.UAS.GFP}, Scer\GAL4^Ddc.PU has short lived phenotype, suppressible | partially by Hsap\PRDX2^UAS.cCa, Scer\GAL4^Ddc.PU

(Chua et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\LRRK2^{G2019S.UAS.GFP}, Scer\GAL4^Ddc.PU has adult dopaminergic neuron | decreased number phenotype, suppressible | partially by Hsap\PRDX2^UAS.cCa, Scer\GAL4^Ddc.PU

(Chua et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\LRRK2^{G2019S.UAS.GFP}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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