FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term larval inner optic anlage ID (Ontology) FBbt:00001951 (Fly Anatomy)
Definition A ribbon-like layer of neuroepithelial cells (and later of proliferating neuroblasts) in the larval optic lobe that gives rise to the adult inner medulla, lobula and lobula plate neurons. In early larval stages it is composed of neuroepithelial cells that divide symmetrically. In the early second instar it becomes U shaped, with the opening of the U pointing in a dorso-caudal direction. It becomes distinguished from the outer optic anlage during the second half of the first instar period (Meinertzhagen and Hanson, 1993). In the third instar, neuroepithelial cells in the medial region give rise to neuroblasts that divide asymmetrically to generate the adult optic lobe neurons.[ FlyBase:FBrf0052913 FlyBase:FBrf0193624 ]
Also Known As"embryonic/larval inner optic anlage" ; "IOA"
Comment'proliferation center' synonyms usually used for later stages of development (Ngo et al., 2017 - FBrf0236058).
Links to External Ontologies
VFB:FBbt_00001951
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Data ClassFieldDirect annotations
Alleles (FBal)PHENOTYPE_MANIFEST_IN
Insertions (FBti)EXPRESSION_STAGE_TISSUE_POSITION
Insertions (FBti)PHENOTYPE_MANIFEST_IN
Constructs (FBtp)PHENOTYPE_MANIFEST_IN
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Relevant FlyBase reports
 Alleles Genes Insertions Constructs
 larval inner optic anlage (all annotations which use CV term, excluding "NOT" statements)
     larval inner optic anlage | ectopic | third instar larval stage
      --
     larval inner optic anlage | heat sensitive
      --       --       --
     larval inner optic anlage | precursor
      --
      --
     larval inner optic anlage | third instar larval stage
      --       --
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embryonic/larval optic lobe___
anlage________________________|
anterior ectoderm derivative__|
                              larval optic anlage
                               |__larval inner optic anlage  105 rec.
                                   |__inner optic anlage central plug
                                   |__inner optic anlage dorsal proliferation zone 1 rec.
                                   |__inner optic anlage lateral proliferation zone 21 rec.
                                   |__inner optic anlage neuroblast 7 rec.
                                       |__lobula forming neuroblast
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Is a larval optic anlage
Develops from embryonic inner optic lobe primordium
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VFB:FBbt_00001951