FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term subperineurial glial sheath ID (Ontology) FBbt:00007091 (Fly Anatomy)
Definition Inner glial cell layer of the perineurium that is probably not derived from the mesoderm (Edwards et al., 1994). This layer form an ion permeability barrier, functionally similar to the endothelial cells of the mammalian blood-brain barrier (Limmer et al., 2014).[ FlyBase:FBrf0057603 FlyBase:FBrf0058936 FlyBase:FBrf0226917 FlyBase:FBrf0239343 ]
Also Known As"barrier glial cell layer" ; "sub-perineurial glial sheath"
CommentThat the subperineurial glial cells do not derive from the mesoderm is suggested by Edwards et al. (1994), in which they show the presence of these cells in delta (FBgn0000463) mutant embryos. 'Blood-brain barrier' may refer to this (e.g. Morante et al., 2013) or the perineurium (e.g. Limmer et al., 2014), which includes this and the perineurial glial sheath.
Links to External Ontologies
VFB:FBbt_00007091
Annotations
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Data ClassFieldDirect annotations
Alleles (FBal)PHENOTYPE_MANIFEST_IN
Insertions (FBti)PHENOTYPE_MANIFEST_IN
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Relevant FlyBase reports
 Alleles Insertions
 subperineurial glial sheath (all annotations which use CV term, excluding "NOT" statements)
     subperineurial glial sheath | adult stage
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nervous system
 |__perineurium__________
multi-tissue structure   |
 |__perineurium__________|
multicellular structure  |
 |__portion of tissue____|
                         subperineurial glial sheath  247 rec.
                          |__subperineurial glial cell 241 rec.
                              |__adult subperineurial glial cell(+) 45 rec.
                              |__CNS subperineurial glial cell(+) 118 rec.
                              |__embryonic/larval subperineurial glial cell(+) 131 rec.
                              |__PNS subperineurial glial cell(+) 26 rec.
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Is a portion of tissue
Part of perineurium
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Synonyms
  • "barrier glial cell layer" EXACT
    "blood-brain barrier" RELATED[ FlyBase:FBrf0223187 ]
    "sub-perineurial glial sheath" EXACT
Secondary IDs
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VFB:FBbt_00007091